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Despite its relative youth it has established itself as a premier gaming platform for casinos. Wolves is one of the latest games, a 5-reel slot machine that has a high RTP and stunning graphics. Other notable games include Wolf Gold and Chilli Heat.<br><br>Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are typically commissioned by practitioners and policy makers to guide their decision-making. They can also be used to determine the causality of an intervention with its outcomes. However, they shouldn't be used to substitute for the use of explanation studies.<br><br>The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 made the distinction between explanation studies, which confirm the physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform the decision-making process for policy and practice. 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