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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are usually focused on the practical aspects of the research design, like the recruitment and consent process, adherence, and the use of routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which used various investigators and participants from different geographical regions. This kind of heterogeneity is necessary for practical trials to be valid and helps to reduce the chance of bias in the results. However excessive heterogeneity could result in issues with the design of the trial.

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The goal of pragmatic trials is to mimic real-life scenarios and to achieve maximum validity externally. Usually, they are requested by practitioners and policymakers in order to inform their decisions. They can also be used to determine the cause-effect relationship of an intervention and its effects. However, they shouldn't be used as a substitute for explanatory studies.

The pragmatism idea is controversial and there are doubts about whether pragmatic trials should replace explanatory tests or if they are an addition to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm the clinical or physiological hypothesis as well as pragmatic trials that inform the policy and practice of. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the elements of a practical study that includes recruitment, design, delivery of the intervention, and follow-up.

There is a positive increase in the number of pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, 프라그마틱 슬롯 무료체험 which was limited to randomized controlled trials (RCTs), yielded 34 articles, shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to remember that the majority of studies were conducted in primary-care settings.