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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often described as a focus on the practical aspects of study design which include the recruitment and consent process, as well as adherence and the use routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and participants from different geographic areas. This type of heterogeneity is necessary for pragmatic trials to be able to prove their validity and also helps to reduce bias in the results. Too much heterogeneity, however, can cause problems with the trial design.

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The purpose of pragmatic trials is to replicate real-life scenarios and to achieve maximum validity externally. They are usually commissioned by policy makers and practitioners to aid in their decision-making. They can also be used to assess the causal relationship between an intervention and its results. They should, however, not be used to replace the need for explanation studies.

The concept of pragmatism is controversial and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm a physiological or clinical hypothesis as well as pragmatic trials, which guide the policy and practice of. They also proposed the framework for pragmatic trials, called PRECIS.2 This tool attempted to define the elements of a pragmatic trial, including recruitment, 프라그마틱 슬롯 design and delivery of the intervention, and follow-up.

The number of pragmatic trials is growing. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) produced 34 articles, shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to remember, however, that the majority of studies were conducted in primary care settings.