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Pragmatic trials are trials designed to inform the practice of clinical trials in real life. They are typically described as focusing on practical aspects of study design, including recruitment and consent, adherence and the use of standard equipment.

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Pragmatic is a software development company that offers a broad range of casino games available on online gambling platforms. Pragmatic's iGaming solutions are used by the top operators and casinos with a physical location. The company offers front-end website design tools, analysis tools and marketing, promotions security, payment systems, customer support and bug-reporting. Additionally, the company offers its players a safe and secure environment with high-quality graphics as well as games.

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A pragmatic trial that uses various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is necessary for pragmatic trials to be able to prove their validity and also helps reduce bias in the results. A high degree of heterogeneity, however, can cause problems with the trial design.

Pragmatic Play is also a major player on the live casino market, providing an extensive selection of table games like as Blackjack and Roulette in various versions. The live studios of the company in Romania and Malta provide a genuine gaming experience for its customers and offer a wide range of virtual betting options. The company also offers a variety of games which make online gambling exciting and interactive. Some of these shows are telecast live and others feature famous personalities in the field.

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Legality

Pragmatic Play is known for its top-quality games and for providing a superior user experience. Its software can be used on mobile devices as well as in various languages. Despite its infancy it has already established itself as a leading gaming platform for casinos. Its latest releases include Wolves which is a five-reel video slot that has a healthy RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials seek to replicate real-world situations and have the highest external validity. They are usually ordered by policymakers and practitioners to guide their decisions. They are also a good method to determine the cause-effect relationship between an intervention and its results. However, they should not be used to replace explanation studies.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should replace explanatory tests or if they should serve as an alternative to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis as well as pragmatic trials, which guide the policy and practice of. They also suggested the framework for pragmatic trials, dubbed PRECIS.2 This tool was designed to define the elements of a pragmatic trial, including recruitment, design and delivery of the intervention, and monitoring.

There is a positive trend in the number of pragmatic trials that are published. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. However, it is important to note that the majority of these trials were conducted in primary care settings.