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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often focused on practical aspects of the study design, including the recruitment process and consent, adherence, and the use of routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed different investigators and 프라그마틱 홈페이지 included participants from different geographical regions. This type of heterogeneity, 프라그마틱 슬롯 사이트 that is crucial for a pragmatic trial to be reliable and lessen the chance of bias, is also necessary. However excessive heterogeneity could lead to problems with the design of the trial.

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The goal of pragmatic trials is to simulate real-life scenarios and to achieve the highest level of validity externally. Usually, they are requested by practitioners and policymakers in order to guide their decisions. They can also be a great method to determine the causal relationship between the intervention and its effects. However, they shouldn't be used to substitute for the use of explanation studies.

The pragmatism idea is controversial and there are concerns about whether pragmatic trials can be used to replace explanation tests or if they should serve as an addition to them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which confirm a physiological hypothesis or clinical hypothesis, and pragmatic trials that aid in the practice and policy decision-making. They also suggested an approach to pragmatic trials, which they called PRECIS.2 This tool was designed to define the characteristics of a pragmatic trial that include the recruitment process, the design and implementation of the intervention, and monitoring.

There is a positive increase in the number of pragmatic trials published. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This is an indication that the health science community is becoming more acquaint to the subject of pragmatic thinking. It is important to note, however, that the majority were conducted in primary care settings.