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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often characterized as focusing on practical aspects of designing a study, including recruitment and consent, adherence and the use of routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and had participants from different geographic areas. This kind of heterogeneity, that is crucial for pragmatic trials to be valid and 프라그마틱 추천 lessen the chance of bias, is also necessary. However too much heterogeneity could cause problems with the design of the trial.

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The goal of pragmatic trials is to mimic real-life situations and achieve maximum validity externally. They are usually commissioned by policy makers and practitioners to aid in their decision-making. They can also be a great method of determining the cause-effect relationship between an intervention and its outcomes. However, they should not be used to substitute for explanation studies.

The pragmatism idea is controversial, and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove the clinical or physiological hypothesis as well as pragmatic trials, which guide policy and practice decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic study that includes recruitment, design, implementation of the intervention and its follow-up.

The number of pragmatic trials is growing. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to note that the majority of these studies were conducted in primary care settings.