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Pragmatic trials are studies designed to inform the practice of clinical trials in real life. They are typically described by their focus on practical aspects of design which include the recruitment process and consent, adhering and the use of routinely available equipment.

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Pragmatic is a software developer that offers a wide range of casino games available on online gambling platforms. Pragmatic's iGaming solutions are used by the most reputable operators as well as casinos that are located in the land. The company offers front-end tools for design, analysis, promotions, marketing, payment systems, security, customer service and bug reporting. Additionally, the company offers its players a safe and secure environment with high-quality graphics and gaming.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed different investigators and included participants from different geographical regions. This type of heterogeneity, which is vital for pragmatic trials to be reliable and to reduce bias in the results is also essential. However excessive heterogeneity could result in problems with the design of the trial.

Pragmatic Play is also a major player in the live casino market, providing a wide selection of classic table games such as Blackjack and Roulette in various versions. The live studios of the company in Romania and Malta offer a real-life gaming experience for its customers and offer a full suite of virtual betting options. The company also offers a variety of games which make online gambling fun and interactive. Some of these shows have live hosts, while others are hosted by famous personalities from the industry.

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Pragmatic Play is a relatively new player in the world of online casinos, but it has made a name for itself by offering mobile-friendly slots. Their games are optimised for mobile devices and operate on HTML5 technology. They're also endorsed by reputable gaming authorities to ensure fairness and transparency. This is a good indicator for players because it means the games have been tested and verified to ensure randomness and fairness of each round.

Pragmatic Play offers not only mobile-friendly slot machines, but also live casino and table games. The company is licensed and is regulated by various governing bodies which include the Malta Gaming Authority and UK Gambling Commission. The games of the company are protected by high-end encryption, and its security team is on hand to help players with any issues.

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Pragmatic Play is renowned for its top-notch games, and also for providing an outstanding user experience. Its software is designed to work on mobile devices and supports different languages. Despite its relative youth it has already established itself as a leading casino gaming platform. Its latest releases include Wolves, a 5-reel video slot that has a healthy RTP and stunning graphics. Other notable games include Wolf Gold and Chilli Heat.

Pragmatic trials seek to replicate real-world situations and have the highest external validity. They are usually requested by policy makers and practitioners to inform their decision making. They can also be used to assess the causal relationship between an intervention and its results. They should not, however be used to replace explanatory studies.

The idea of pragmatism is controversial, and there are questions about whether pragmatic trials can replace explanatory tests or if they should be an addition to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which prove a physiological or clinical hypothesis as well as pragmatic trials, which guide policy and practice decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the elements of a practical study which includes the recruitment, design, and delivery of the intervention, and follow-up.

There is a positive increase in the number pragmatic trials that have been published. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming increasingly sensitized to the issue of pragmatics. However, it is important to keep in mind that the majority of these trials were conducted in primary care settings.