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Pragmatic Free Trial Meta<br><br>Pragmatic Free Trial Meta is a free and non-commercial open data platform and infrastructure that facilitates research on pragmatic trials. It collects and distributes clean trial data, ratings, and evaluations using PRECIS-2. This allows for a variety of meta-epidemiological analyses to examine the effect of treatment across trials with different levels of pragmatism.<br><br>Background<br><br>Pragmatic trials are becoming more widely recognized as providing real-world evidence for clinical decision-making. However, the usage of the term "pragmatic" is not uniform and its definition and evaluation requires further clarification. The purpose of pragmatic trials is to guide clinical practices and policy decisions, not to confirm a physiological hypothesis or clinical hypothesis. A pragmatic trial should also aim to be as similar to real-world clinical practice as possible, including in its participation of participants, setting and design, the delivery and execution of the intervention, determination and analysis of the outcomes, and primary analysis. This is a key distinction from explanatory trials (as described by Schwartz and Lellouch1) which are intended to provide a more complete confirmation of the hypothesis.<br><br>Studies that are truly practical should not attempt to blind participants or healthcare professionals, as this may lead to bias in the estimation of treatment effects. Pragmatic trials will also recruit patients from various healthcare settings to ensure that the results can be generalized to the real world.<br><br>Finally studies that are pragmatic should focus on outcomes that are vital to patients, like quality of life or functional recovery. This is particularly important in trials that involve surgical procedures that are invasive or have potentially dangerous adverse events. The CRASH trial29, for instance focused on the functional outcome to compare a two-page report with an electronic system to monitor the health of patients in hospitals suffering from chronic heart failure. Similarly, the catheter trial28 focused on symptomatic catheter-associated urinary tract infections as the primary outcome.<br><br>In addition to these features, pragmatic trials should minimize the requirements for data collection and trial procedures to cut costs and time commitments. Additionally the aim of pragmatic trials is to make their results as relevant to actual clinical practice as is possible. This can be accomplished by ensuring that their analysis is based on the intention-to treat approach (as described within CONSORT extensions).<br><br>Despite these criteria however, [https://images.google.cf/url?q=https://squareblogs.net/kenyaline7/10-pragmatic-slot-experience-that-are-unexpected 프라그마틱 무료] 추천 ([https://www.northwestu.edu/?URL=http://nutris.net/members/carpmask84/activity/1848434/ click the following internet site]) a large number of RCTs with features that challenge pragmatism have been incorrectly self-labeled pragmatic and published in journals of all kinds. This can lead to misleading claims of pragmatism, and the usage of the term should be standardized. The development of a PRECIS-2 tool that offers a standardized objective assessment of pragmatic features is the first step.<br><br>Methods<br><br>In a practical trial it is the intention to inform policy or clinical decisions by demonstrating how the intervention can be implemented into routine care. Explanatory trials test hypotheses about the cause-effect relation within idealized conditions. In this way, pragmatic trials can have a lower internal validity than explanation studies and are more susceptible to biases in their design analysis, conduct, and design. Despite these limitations, pragmatic trials may provide valuable information to decision-making in the context of healthcare.<br><br>The PRECIS-2 tool scores an RCT on 9 domains, ranging from 1 to 5 (very pragmatic). In this study,  [https://hikvisiondb.webcam/wiki/Mayerdonnelly1054 프라그마틱 슬롯 무료체험] 슬롯버프, [https://marvelvsdc.faith/wiki/Undeniable_Proof_That_You_Need_Pragmatickr Read A lot more], the recruitment, organisation, flexibility: delivery, flexible adherence and follow-up domains received high scores, but the primary outcome and the method of missing data were not at the practical limit. This suggests that a trial could be designed with good pragmatic features, without compromising its quality.<br><br>It is, however, difficult to determine how practical a particular trial really is because pragmaticity is not a definite quality; certain aspects of a trial may be more pragmatic than others. Additionally, logistical or protocol modifications made during the trial may alter its score on pragmatism. In addition, 36% of the 89 pragmatic trials discovered by Koppenaal and colleagues were placebo-controlled or conducted prior to licensing and most were single-center. They are not in line with the standard practice and are only called pragmatic if their sponsors accept that these trials are not blinded.<br><br>A common feature of pragmatic studies is that researchers attempt to make their findings more relevant by studying subgroups within the trial sample. This can result in unbalanced analyses with lower statistical power. This increases the risk of omitting or ignoring differences in the primary outcomes. In the case of the pragmatic trials included in this meta-analysis, this was a serious issue because the secondary outcomes were not adjusted for differences in baseline covariates.<br><br>Furthermore practical trials can have challenges with respect to the gathering and interpretation of safety data. This is because adverse events are typically reported by participants themselves and are susceptible to reporting errors, delays or  [https://www.metooo.com/u/66eaf37cb6d67d6d17862122 라이브 카지노] coding errors. Therefore, it is crucial to enhance the quality of outcomes ascertainment in these trials, and ideally by using national registry databases instead of relying on participants to report adverse events on the trial's own database.<br><br>Results<br><br>Although the definition of pragmatism does not mean that trials must be 100 100% pragmatic, there are some advantages to including pragmatic components in clinical trials. These include:<br><br>Incorporating routine patients, the trial results can be more quickly translated into clinical practice. However, pragmatic trials may also have drawbacks. The right type of heterogeneity, like could help a study generalise its findings to many different settings or patients. However, the wrong type can decrease the sensitivity of the test and, consequently, reduce a trial's power to detect minor treatment effects.<br><br>Several studies have attempted to classify pragmatic trials using different definitions and scoring methods. Schwartz and Lellouch1 have developed a framework that can discern between explanation-based studies that confirm a physiological hypothesis or clinical hypothesis and pragmatic studies that inform the selection of appropriate treatments in real world clinical practice. Their framework included nine domains that were scored on a scale ranging from 1 to 5 with 1 being more informative and 5 indicating more practical. The domains included recruitment and setting, delivery of intervention with flexibility, follow-up and primary analysis.<br><br>The initial PRECIS tool3 featured similar domains and a scale of 1 to 5. Koppenaal et. al10 devised an adaptation of the assessment, known as the Pragmascope, that was easier to use for systematic reviews. They discovered that pragmatic reviews scored higher in all domains, but scored lower in the primary analysis domain.<br><br>This distinction in the primary analysis domain could be due to the fact that the majority of pragmatic trials analyze their data in the intention to treat manner while some explanation trials do not. The overall score for systematic reviews that were pragmatic was lower when the areas of organization, flexible delivery, and following-up were combined.<br><br>It is important to note that the term "pragmatic trial" does not necessarily mean a low quality trial, and indeed there is an increasing rate of clinical trials (as defined by MEDLINE search, however this is not specific or sensitive) which use the word "pragmatic" in their abstract or title. These terms may signal a greater awareness of pragmatism within abstracts and titles, however it isn't clear if this is reflected in content.<br><br>Conclusions<br><br>As the importance of evidence from the real world becomes more commonplace the pragmatic trial has gained momentum in research. They are randomized trials that evaluate real-world alternatives to clinical trials in development. They involve patient populations more closely resembling those treated in regular medical care. This method is able to overcome the limitations of observational research like the biases that come with the reliance on volunteers and the lack of coding variations in national registries.<br><br>Pragmatic trials also have advantages, including the ability to leverage existing data sources and a greater chance of detecting significant differences from traditional trials. However, they may have some limitations that limit their validity and generalizability. For example the rates of participation in some trials might be lower than expected due to the healthy-volunteer effect as well as financial incentives or competition for participants from other research studies (e.g., industry trials). The necessity to recruit people in a timely manner also reduces the size of the sample and the impact of many pragmatic trials. Certain pragmatic trials lack controls to ensure that any observed differences aren't due to biases during the trial.<br><br>The authors of the Pragmatic Free Trial Meta identified 48 RCTs that self-labeled themselves as pragmatist and published up to 2022. They assessed pragmatism using the PRECIS-2 tool, which includes the domains eligibility criteria as well as recruitment, flexibility in intervention adherence and follow-up. They found that 14 of these trials scored highly or pragmatic sensible (i.e. scores of 5 or higher) in one or more of these domains, and that the majority of them were single-center.<br><br>Trials with a high pragmatism score tend to have broader eligibility criteria than traditional RCTs which have very specific criteria that are not likely to be present in the clinical environment, and they contain patients from a broad variety of hospitals. The authors argue that these traits can make pragmatic trials more meaningful and useful for everyday clinical practice, however they do not necessarily guarantee that a trial using a pragmatic approach is free from bias. The pragmatism is not a definite characteristic and a test that does not possess all the characteristics of an explicative study could still yield valuable and valid results.
Pragmatic Free Trial Meta<br><br>Pragmatic Free Trail Meta is an open data platform that enables research into pragmatic trials. It is a platform that collects and shares clean trial data and ratings using PRECIS-2 which allows for multiple and varied meta-epidemiological research studies to evaluate the effect of treatment on trials with different levels of pragmatism and other design features.<br><br>Background<br><br>Pragmatic trials provide evidence from the real world that can be used to make clinical decisions. The term "pragmatic" however, is a word that is often used in contradiction and its definition and assessment need further clarification. Pragmatic trials are designed to inform clinical practices and policy decisions, not to confirm a physiological hypothesis or clinical hypothesis. A pragmatic trial should aim to be as similar to actual clinical practice as is possible, including its participation of participants, setting and design, the delivery and execution of the intervention, and the determination and analysis of outcomes and primary analysis. This is a significant difference between explanatory trials, as defined by Schwartz &amp; Lellouch1 which are designed to confirm a hypothesis in a more thorough way.<br><br>Truely pragmatic trials should not be blind participants or the clinicians. This can lead to a bias in the estimates of the effect of treatment. The trials that are pragmatic should also try to enroll patients from a wide range of health care settings, to ensure that their findings are generalizable to the real world.<br><br>Furthermore, trials that are pragmatic must concentrate on outcomes that are important to patients, like the quality of life and functional recovery. This is especially important in trials that require invasive procedures or have potentially dangerous adverse impacts. The CRASH trial29, for instance, focused on functional outcomes to evaluate a two-page case report with an electronic system for monitoring of patients in hospitals suffering from chronic heart failure, and the catheter trial28 focused on urinary tract infections that are symptomatic of catheters as the primary outcome.<br><br>In addition to these aspects the pragmatic trial should also reduce the procedures for conducting trials and data collection requirements to reduce costs. Finaly the aim of pragmatic trials is to make their findings as relevant to real-world clinical practices as possible. This can be accomplished by ensuring that their analysis is based on the intention-to treat approach (as defined in CONSORT extensions).<br><br>Despite these criteria however, a large number of RCTs with features that challenge pragmatism have been incorrectly self-labeled pragmatic and published in journals of all types. This could lead to misleading claims of pragmaticity and the use of the term needs to be standardized. The development of a PRECIS-2 tool that offers an objective and standardized evaluation of the pragmatic characteristics is a first step.<br><br>Methods<br><br>In a pragmatic study it is the intention to inform clinical or policy decisions by showing how an intervention could be incorporated into real-world routine care. Explanatory trials test hypotheses regarding the cause-effect relationship within idealised environments. In this way, pragmatic trials could have less internal validity than explanation studies and be more prone to biases in their design as well as analysis and conduct. Despite these limitations, pragmatic trials may be a valuable source of information for decision-making in healthcare.<br><br>The PRECIS-2 tool assesses the degree of pragmatism in an RCT by assessing it on 9 domains, ranging from 1 (very explanatory) to 5 (very pragmatic). In this study the areas of recruitment, organization, flexibility in delivery,  [https://www.google.com.om/url?q=http://ezproxy.cityu.edu.hk/login?url=https://pragmatickr.com/ 프라그마틱 사이트] 무료게임 ([http://ezproxy.cityu.edu.hk/login?url=https://www.metooo.com/u/66e59b6f9854826d166c3619 linked web-site]) flexibility in adherence, and follow-up scored high. However, the primary outcome and the method of missing data was scored below the pragmatic limit. This suggests that it is possible to design a trial with excellent pragmatic features without damaging the quality of its outcomes.<br><br>However, it's difficult to determine how practical a particular trial is since the pragmatism score is not a binary attribute; some aspects of a trial can be more pragmatic than others. The pragmatism of a trial can be affected by modifications to the protocol or the logistics during the trial. Koppenaal and colleagues discovered that 36% of 89 pragmatic studies were placebo-controlled, or conducted prior to the licensing. The majority of them were single-center. This means that they are not quite as typical and can only be described as pragmatic in the event that their sponsors are supportive of the lack of blinding in such trials.<br><br>Additionally,  [https://maps.google.com.tr/url?q=https://selfless.wiki/wiki/12_Companies_Are_Leading_The_Way_In_Pragmatic_Authenticity_Verification 프라그마틱 슬롯 무료체험] 이미지 - [https://blogfreely.net/eggnogbill50/8-tips-to-enhance-your-pragmatic-slot-tips-game Blogfreely.Net] - a typical feature of pragmatic trials is that the researchers attempt to make their findings more relevant by analyzing subgroups of the trial sample. This can lead to unbalanced analyses that have lower statistical power. This increases the possibility of omitting or misinterpreting differences in the primary outcomes. This was a problem during the meta-analysis of pragmatic trials as secondary outcomes were not corrected for differences in covariates at the time of baseline.<br><br>Additionally, studies that are pragmatic can present challenges in the collection and interpretation of safety data. This is due to the fact that adverse events are typically reported by participants themselves and prone to reporting delays, inaccuracies, or coding variations. It is essential to increase the accuracy and quality of the outcomes in these trials.<br><br>Results<br><br>While the definition of pragmatism does not require that all clinical trials are 100% pragmatist there are benefits to including pragmatic components in trials. These include:<br><br>Incorporating routine patients, the results of the trial can be translated more quickly into clinical practice. However, pragmatic studies can also have drawbacks. For instance, the appropriate kind of heterogeneity can allow a study to generalize its results to many different settings and patients. However the wrong kind of heterogeneity could reduce assay sensitivity, and thus reduce the power of a study to detect small treatment effects.<br><br>A variety of studies have attempted to categorize pragmatic trials using various definitions and scoring methods. Schwartz and Lellouch1 created a framework to discern between explanation-based studies that prove the physiological hypothesis or clinical hypothesis, and pragmatic studies that help inform the selection of appropriate therapies in real world clinical practice. The framework was comprised of nine domains that were scored on a scale ranging from 1 to 5 with 1 indicating more lucid and 5 indicating more practical. The domains included recruitment setting, setting, intervention delivery with flexibility, follow-up and primary analysis.<br><br>The original PRECIS tool3 featured similar domains and scales from 1 to 5. Koppenaal and colleagues10 developed an adaptation of this assessment called the Pragmascope which was more user-friendly to use in systematic reviews. They found that pragmatic systematic reviews had higher average scores across all domains but lower scores in the primary analysis domain.<br><br>The difference in the primary analysis domain could be due to the fact that the majority of pragmatic trials analyze their data in an intention to treat way however some explanation trials do not. The overall score for pragmatic systematic reviews was lower when the areas of organization, flexible delivery, and following-up were combined.<br><br>It is important to note that the term "pragmatic trial" does not necessarily mean a poor quality trial, and indeed there is a growing number of clinical trials (as defined by MEDLINE search, but this is not sensitive nor specific) which use the word "pragmatic" in their abstract or title. The use of these terms in abstracts and titles could indicate a greater understanding of the importance of pragmatism, but it is unclear whether this is evident in the contents of the articles.<br><br>Conclusions<br><br>As the importance of evidence from the real world becomes more popular and pragmatic trials have gained popularity in research. They are clinical trials randomized that evaluate real-world alternatives to care rather than experimental treatments under development, they include patients that more closely mirror those treated in routine care, they employ comparators that are used in routine practice (e.g. existing drugs), and they rely on participant self-report of outcomes. This method has the potential to overcome the limitations of observational research which include the biases that arise from relying on volunteers and the lack of availability and coding variability in national registry systems.<br><br>Other advantages of pragmatic trials include the possibility of using existing data sources, as well as a higher likelihood of detecting meaningful changes than traditional trials. However, these tests could have some limitations that limit their validity and generalizability. For instance, participation rates in some trials might be lower than expected due to the healthy-volunteer effect and financial incentives or competition for participants from other research studies (e.g., industry trials). Many pragmatic trials are also restricted by the necessity to recruit participants quickly. Certain pragmatic trials lack controls to ensure that observed differences aren't due to biases in the trial.<br><br>The authors of the Pragmatic Free Trial Meta identified 48 RCTs self-labeled as pragmatist and published up to 2022. The PRECIS-2 tool was used to assess the pragmatism of these trials. It includes domains such as eligibility criteria and flexibility in recruitment, adherence to intervention, and follow-up. They found that 14 trials scored highly pragmatic or pragmatic (i.e. scoring 5 or above) in at least one of these domains.<br><br>Trials with high pragmatism scores are likely to have more criteria for eligibility than traditional RCTs. They also include patients from a variety of hospitals. The authors claim that these characteristics can help make pragmatic trials more meaningful and applicable to daily practice, but they do not guarantee that a trial using a pragmatic approach is free of bias. In addition, the pragmatism that is present in the trial is not a fixed attribute A pragmatic trial that doesn't contain all the characteristics of a explanatory trial can yield valuable and reliable results.

Revision as of 16:10, 21 December 2024

Pragmatic Free Trial Meta

Pragmatic Free Trail Meta is an open data platform that enables research into pragmatic trials. It is a platform that collects and shares clean trial data and ratings using PRECIS-2 which allows for multiple and varied meta-epidemiological research studies to evaluate the effect of treatment on trials with different levels of pragmatism and other design features.

Background

Pragmatic trials provide evidence from the real world that can be used to make clinical decisions. The term "pragmatic" however, is a word that is often used in contradiction and its definition and assessment need further clarification. Pragmatic trials are designed to inform clinical practices and policy decisions, not to confirm a physiological hypothesis or clinical hypothesis. A pragmatic trial should aim to be as similar to actual clinical practice as is possible, including its participation of participants, setting and design, the delivery and execution of the intervention, and the determination and analysis of outcomes and primary analysis. This is a significant difference between explanatory trials, as defined by Schwartz & Lellouch1 which are designed to confirm a hypothesis in a more thorough way.

Truely pragmatic trials should not be blind participants or the clinicians. This can lead to a bias in the estimates of the effect of treatment. The trials that are pragmatic should also try to enroll patients from a wide range of health care settings, to ensure that their findings are generalizable to the real world.

Furthermore, trials that are pragmatic must concentrate on outcomes that are important to patients, like the quality of life and functional recovery. This is especially important in trials that require invasive procedures or have potentially dangerous adverse impacts. The CRASH trial29, for instance, focused on functional outcomes to evaluate a two-page case report with an electronic system for monitoring of patients in hospitals suffering from chronic heart failure, and the catheter trial28 focused on urinary tract infections that are symptomatic of catheters as the primary outcome.

In addition to these aspects the pragmatic trial should also reduce the procedures for conducting trials and data collection requirements to reduce costs. Finaly the aim of pragmatic trials is to make their findings as relevant to real-world clinical practices as possible. This can be accomplished by ensuring that their analysis is based on the intention-to treat approach (as defined in CONSORT extensions).

Despite these criteria however, a large number of RCTs with features that challenge pragmatism have been incorrectly self-labeled pragmatic and published in journals of all types. This could lead to misleading claims of pragmaticity and the use of the term needs to be standardized. The development of a PRECIS-2 tool that offers an objective and standardized evaluation of the pragmatic characteristics is a first step.

Methods

In a pragmatic study it is the intention to inform clinical or policy decisions by showing how an intervention could be incorporated into real-world routine care. Explanatory trials test hypotheses regarding the cause-effect relationship within idealised environments. In this way, pragmatic trials could have less internal validity than explanation studies and be more prone to biases in their design as well as analysis and conduct. Despite these limitations, pragmatic trials may be a valuable source of information for decision-making in healthcare.

The PRECIS-2 tool assesses the degree of pragmatism in an RCT by assessing it on 9 domains, ranging from 1 (very explanatory) to 5 (very pragmatic). In this study the areas of recruitment, organization, flexibility in delivery, 프라그마틱 사이트 무료게임 (linked web-site) flexibility in adherence, and follow-up scored high. However, the primary outcome and the method of missing data was scored below the pragmatic limit. This suggests that it is possible to design a trial with excellent pragmatic features without damaging the quality of its outcomes.

However, it's difficult to determine how practical a particular trial is since the pragmatism score is not a binary attribute; some aspects of a trial can be more pragmatic than others. The pragmatism of a trial can be affected by modifications to the protocol or the logistics during the trial. Koppenaal and colleagues discovered that 36% of 89 pragmatic studies were placebo-controlled, or conducted prior to the licensing. The majority of them were single-center. This means that they are not quite as typical and can only be described as pragmatic in the event that their sponsors are supportive of the lack of blinding in such trials.

Additionally, 프라그마틱 슬롯 무료체험 이미지 - Blogfreely.Net - a typical feature of pragmatic trials is that the researchers attempt to make their findings more relevant by analyzing subgroups of the trial sample. This can lead to unbalanced analyses that have lower statistical power. This increases the possibility of omitting or misinterpreting differences in the primary outcomes. This was a problem during the meta-analysis of pragmatic trials as secondary outcomes were not corrected for differences in covariates at the time of baseline.

Additionally, studies that are pragmatic can present challenges in the collection and interpretation of safety data. This is due to the fact that adverse events are typically reported by participants themselves and prone to reporting delays, inaccuracies, or coding variations. It is essential to increase the accuracy and quality of the outcomes in these trials.

Results

While the definition of pragmatism does not require that all clinical trials are 100% pragmatist there are benefits to including pragmatic components in trials. These include:

Incorporating routine patients, the results of the trial can be translated more quickly into clinical practice. However, pragmatic studies can also have drawbacks. For instance, the appropriate kind of heterogeneity can allow a study to generalize its results to many different settings and patients. However the wrong kind of heterogeneity could reduce assay sensitivity, and thus reduce the power of a study to detect small treatment effects.

A variety of studies have attempted to categorize pragmatic trials using various definitions and scoring methods. Schwartz and Lellouch1 created a framework to discern between explanation-based studies that prove the physiological hypothesis or clinical hypothesis, and pragmatic studies that help inform the selection of appropriate therapies in real world clinical practice. The framework was comprised of nine domains that were scored on a scale ranging from 1 to 5 with 1 indicating more lucid and 5 indicating more practical. The domains included recruitment setting, setting, intervention delivery with flexibility, follow-up and primary analysis.

The original PRECIS tool3 featured similar domains and scales from 1 to 5. Koppenaal and colleagues10 developed an adaptation of this assessment called the Pragmascope which was more user-friendly to use in systematic reviews. They found that pragmatic systematic reviews had higher average scores across all domains but lower scores in the primary analysis domain.

The difference in the primary analysis domain could be due to the fact that the majority of pragmatic trials analyze their data in an intention to treat way however some explanation trials do not. The overall score for pragmatic systematic reviews was lower when the areas of organization, flexible delivery, and following-up were combined.

It is important to note that the term "pragmatic trial" does not necessarily mean a poor quality trial, and indeed there is a growing number of clinical trials (as defined by MEDLINE search, but this is not sensitive nor specific) which use the word "pragmatic" in their abstract or title. The use of these terms in abstracts and titles could indicate a greater understanding of the importance of pragmatism, but it is unclear whether this is evident in the contents of the articles.

Conclusions

As the importance of evidence from the real world becomes more popular and pragmatic trials have gained popularity in research. They are clinical trials randomized that evaluate real-world alternatives to care rather than experimental treatments under development, they include patients that more closely mirror those treated in routine care, they employ comparators that are used in routine practice (e.g. existing drugs), and they rely on participant self-report of outcomes. This method has the potential to overcome the limitations of observational research which include the biases that arise from relying on volunteers and the lack of availability and coding variability in national registry systems.

Other advantages of pragmatic trials include the possibility of using existing data sources, as well as a higher likelihood of detecting meaningful changes than traditional trials. However, these tests could have some limitations that limit their validity and generalizability. For instance, participation rates in some trials might be lower than expected due to the healthy-volunteer effect and financial incentives or competition for participants from other research studies (e.g., industry trials). Many pragmatic trials are also restricted by the necessity to recruit participants quickly. Certain pragmatic trials lack controls to ensure that observed differences aren't due to biases in the trial.

The authors of the Pragmatic Free Trial Meta identified 48 RCTs self-labeled as pragmatist and published up to 2022. The PRECIS-2 tool was used to assess the pragmatism of these trials. It includes domains such as eligibility criteria and flexibility in recruitment, adherence to intervention, and follow-up. They found that 14 trials scored highly pragmatic or pragmatic (i.e. scoring 5 or above) in at least one of these domains.

Trials with high pragmatism scores are likely to have more criteria for eligibility than traditional RCTs. They also include patients from a variety of hospitals. The authors claim that these characteristics can help make pragmatic trials more meaningful and applicable to daily practice, but they do not guarantee that a trial using a pragmatic approach is free of bias. In addition, the pragmatism that is present in the trial is not a fixed attribute A pragmatic trial that doesn't contain all the characteristics of a explanatory trial can yield valuable and reliable results.