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Pragmatic trials are those that are designed to provide information for the real-world practice of clinical. They are typically characterized by a focus on the practical aspects of the study design, such as the recruitment and consent process as well as adherence to the use of routinely available equipment.

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A pragmatic trial that uses various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is essential for pragmatic trials to be valid and lessen the chance of bias, is also necessary. However excessive heterogeneity could result in issues with the design of the trial.

Pragmatic Play Pragmatic Play, one of the biggest players on the live casino market, provides an array of traditional table games such as Blackjack and Roulette. The live studios of the company in Romania and Malta offer a real-life gambling experience for customers and offer a full suite of virtual betting options. The company also has several games that make online gambling exciting and interactive. Some of these shows are hosted live and others are hosted by famous personalities from the field.

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The aim of pragmatic trials is to replicate real-life situations and achieve the highest level of validity externally. They are usually requested by practitioners and policymakers in order to inform their decisions. They also provide a useful method of determining the causality between an intervention and its outcomes. They should, however, not, be used to replace explanation studies.

The pragmatism idea is controversial, and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate a physiological or clinical hypothesis and pragmatic trials, which guide policy and practice decisions. They also suggested the framework for pragmatic trials, dubbed PRECIS.2 This tool was designed to define the elements of a pragmatic trial, including recruitment, design and delivery of the intervention, as well as monitoring.

There is a positive increase in the number pragmatic trials published. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to keep in mind, however, that the majority of studies were conducted in primary-care settings.