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Pragmatic trials are those that are designed to provide information for the practice of clinical trials in real life. They are often focused on the practical aspects of the study design, such as the recruitment process and consent as well as adherence to the use of standard equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed different investigators and had participants from various geographical areas. This kind of heterogeneity is required for pragmatic trials to be able to prove their validity and helps reduce the chance of bias in the results. Too much heterogeneity, however could cause issues with the design of the trial.

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Pragmatic Play offers not only mobile-friendly slot machines as well as table games and live casino. Pragmatic Play is licensed and regulated by several governing bodies that include the Malta Gaming Authority and UK Gambling Commission. The games of the company are secured with high-end encryption and its security staff is available to assist players with any issues.

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Legality

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Pragmatic trials aim to mimic real-world situations and have the highest external validity. They are usually ordered by policymakers and practitioners in order to guide their decisions. They can be used to determine the causality of an intervention and its effects. However, they shouldn't be used in lieu for 프라그마틱 explanatory trials.

The idea of pragmatism is controversial, and there are questions about whether pragmatic trials should be used to replace explanation tests or if they should be a complement to them. Schwartz and Lellouch1 made an distinction between explanation-based studies, which support a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform the decision-making process for policy and practice. They also proposed an approach to pragmatic trials, called PRECIS.2 This tool was designed to define the characteristics of a pragmatic trial which includes the recruitment process, the design and delivery of the intervention, and monitoring.

There is a positive increase in the number pragmatic trials that are published. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. It is important to note, however, that the majority were conducted in primary care settings.