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Pragmatic trials are those that are designed to provide information for the real-world practice of clinical. They are often described by their focus on practical aspects of designing a study, including recruitment and consent, adherence and the use routinely available equipment.

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Pragmatic is a software development company that offers a wide range of casino games available on online gambling platforms. Its iGaming software is used by the top operators as well as casinos that are located in the land. The company offers front-end design tools, analysis tools, promotions, marketing payment systems, security, customer support and bug reporting. The company also offers security, high-quality graphics, gaming and security.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and had participants from different geographical regions. This kind of heterogeneity is necessary for pragmatic trials to be able to prove their validity, and it also helps reduce the chance of bias in the results. However too much heterogeneity could cause issues with the design of the trial.

Pragmatic Play is also a major player on the live casino market, offering an extensive selection of table games like as Blackjack and Roulette in various variations. The live studios of Pragmatic Play's offices in Romania and Malta offer customers an authentic experience in gambling as well a full range of virtual betting options. The company has also developed several interactive game shows to make online gambling enjoyable. Some of these shows are hosted live, while others feature famous personalities in the industry.

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The goal of pragmatic trials is to replicate real-life situations and achieve maximum validity externally. They are usually requested by practitioners and policy makers to guide their decision-making. They also provide a useful method of determining the causal relationship between the intervention and its effects. However, they should not be used as a substitute for explanation studies.

The concept of pragmatism is controversial and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis as well as pragmatic trials, which guide policy and practice decisions. They also proposed the framework for pragmatic trials, called PRECIS.2 This tool was designed to define the elements of a pragmatic trial that include the recruitment process, the design and delivery of the intervention, and follow-up.

There is an encouraging trend in the number of pragmatic trials that are published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs), yielded 34 articles, as shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to keep in mind that the majority of studies were conducted in primary-care settings.