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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often characterized as a focus on the practical aspects of designing a study that include the recruitment and consent process, as well as adherence and the use of standard equipment.

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A pragmatic study that involves a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is necessary for pragmatic trials to be valid and also helps reduce bias in the results. However too much heterogeneity could cause issues with the design of the trial.

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The purpose of pragmatic trials is to mimic real-life scenarios and gain maximum credibility externally. They are typically commissioned by policy makers and practitioners to aid in their decision-making. They can be used to determine the causality of an intervention with its outcomes. They should, however, not, be used to replace the need for explanation studies.

The pragmatism concept is controversial, and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which support the validity of a physiological or clinical hypothesis, as well as pragmatic trials that aid in the decision-making process for policy and practice. They also suggested a framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the characteristics of a practical trial that include recruitment, design and delivery of the intervention, and monitoring.

There is an encouraging increase in the number of pragmatic trials published. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. However, 프라그마틱 무료체험 메타 it is important to remember that the majority of these studies were conducted in primary care settings.