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Pragmatic trials are those that are designed to inform the real-world practice of clinical. They are often described as focusing on practical aspects of study design which include the recruitment and consent process, as well as adherence and the use routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and included participants from various geographical areas. This kind of heterogeneity is necessary for pragmatic trials to be able to prove their validity and also helps reduce bias in the results. A high degree of heterogeneity, however can result in problems with the design of the trial.

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The aim of pragmatic trials is to mimic real-life scenarios and gain the highest level of validity externally. They are typically commissioned by practitioners and policy makers to guide their decision-making. They can also be used to determine the causality of an intervention and its results. They should not, however, be used to replace the need for explanation studies.

The pragmatism idea is controversial, and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the clinical or physiological hypothesis, and pragmatic trials, which guide the policy and practice of. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a pragmatic study which includes recruitment, design, delivery of the intervention, 프라그마틱 정품인증 and follow-up.

There is a positive trend in the number of pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) produced 34 articles, as shown in red in Figure 2. This is an indication that the health sciences community is becoming more sensitive to the issue of pragmatism. It is important to keep in mind that the majority were conducted in primary-care settings.