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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are often characterized as a focus on the practical aspects of designing a study that include recruitment and consent, adherence and 프라그마틱 무료슬롯; bookmarksoflife.com, the use of routinely available equipment.
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A pragmatic trial that uses different investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is essential for a pragmatic trial to be valid and reduce bias in results is also essential. Too much heterogeneity, however, can cause problems with the design of the trial.
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The aim of pragmatic trials is to replicate real-life scenarios and gain the highest level of validity externally. They are usually ordered by policymakers and practitioners to inform their decisions. They can also be a great way to identify the causality between the intervention and its effects. They should not, however, be used to replace explanatory studies.
The pragmatism idea is controversial and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 proposed an distinction between explanation-based studies, which support the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in policy and practice decision-making. They also proposed a framework called PRECIS for 프라그마틱 슬롯 추천 pragmatic trials.2 This tool tried to define the traits of a practical study, including recruitment, design, delivery of the intervention and its follow-up.
There is a growing increase in the number pragmatic trials that are published. A recent Medline search using the keywords naturalistic and pragmatic, limited to controlled trials randomized to control (RCTs) resulted in 34 articles, shown in red in Figure 2. This is a sign that the health science community is becoming more acquaint to the issue of pragmatics. It is important to note that the majority of these trials were conducted in primary care settings.