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Pragmatic trials are studies designed to provide information for the real-world practice of clinical. They are often focused on practical aspects of the research design, like the recruitment and 프라그마틱 사이트 consent process as well as adherence to the use of standard equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and participants from different geographical regions. This type of heterogeneity is necessary for practical trials to be valid, and it also helps reduce the chance of bias in the results. However excessive heterogeneity could cause issues with the design of the trial.
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The purpose of pragmatic trials is to mimic real-life scenarios and to achieve maximum credibility externally. They are usually commissioned by practitioners and policy makers to guide their decision-making. They also provide a useful method to determine the cause-effect relationship between an intervention and its results. However, they shouldn't be used to substitute for explanatory studies.
The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which support a physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in policy and practice decision-making. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic research study, including recruitment, design, implementation of the intervention and follow-up.
The number of pragmatic trials is increasing. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming more acquaint to the subject of pragmatic thinking. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.