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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are usually focused on the practical aspects of research design, like recruitment and consent as well as adherence to the use of commonly available equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed different investigators and participants from various geographical areas. This kind of heterogeneity, that is crucial for a pragmatic trial to be valid and reduce bias in results is also essential. However too much heterogeneity could cause issues with the design of the trial.
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Pragmatic Play has gained a reputation for offering top-notch games and an exceptional user experience. Its software can be used on mobile devices and in multiple languages. Despite its relative youth it has already established itself as a top gaming platform for casinos. Wolves is one of the most recent releases which is a five-reel slot machine with a healthy RTP and impressive graphics. Its other notable titles are Wolf Gold and Chilli Heat.
Pragmatic trials aim to mimic real-world situations and have the highest external validity. Usually, they are requested by practitioners and policymakers to guide their decisions. They can be used to determine the cause-effect relationship of an intervention and its results. However, they shouldn't be used to substitute for the use of explanation studies.
The concept of pragmatism is controversial and there are doubts about whether pragmatic trials can be used to replace explanation tests or if they should be an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm a physiological or clinical hypothesis and pragmatic trials, which guide the practice and policy decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the traits of a pragmatic research study which includes the recruitment, design, and delivery of the intervention, and follow-up.
The number of pragmatic trials is growing. A recent Medline search using the keywords pragmatic and naturalistic, restricted to randomized controlled trials (RCTs) produced 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community is becoming more sensitive to the issue of pragmatics. However, it is important to remember that the majority of these studies were conducted in primary care settings.