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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are usually characterized by a focus on practical aspects of the research design, like the recruitment process and consent in adherence, as well as the use of commonly available equipment.
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A practical trial that employs a variety investigators and 프라그마틱 무료체험 메타 includes participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for pragmatic trials to be able to prove their validity, and it also reduces the chance of bias in the results. However, too much heterogeneity can result in problems with the design of the trial.
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The goal of pragmatic trials is to simulate real-life scenarios and gain the highest level of validity externally. Usually, they are commissioned by policymakers and practitioners to help guide their decisions. They can also be used to determine the causality of an intervention and its effects. However, they shouldn't be used to substitute for explanatory studies.
The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate a physiological or clinical hypothesis, and pragmatic trials that inform the practice and policy decisions. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic research study that includes recruitment, design, delivery of the intervention and its follow-up.
The number of pragmatic trials is increasing. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This is an indication that the health sciences community is becoming more acquaint to the subject of pragmatic thinking. It is important to keep in mind, however, that the majority of studies were conducted in primary-care settings.