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Studies designed to provide insight into clinical practice in the real world are called pragmatic trials. They are often focused on the practical aspects of research design, like recruitment and consent, adherence, and the use of commonly available equipment.
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A pragmatic trial that uses a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is vital for a pragmatic trial to be reliable and to reduce bias in the results is also essential. However too much heterogeneity could lead to problems with the design of the trial.
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Pragmatic Play has gained a reputation for offering top-notch games and an exceptional user experience. Its software can be used on mobile devices and in multiple languages. Despite its relatively young age, it has already established itself as a leading gaming platform for casinos. Its latest releases include Wolves which is a five-reel video slot with a healthful RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.
The aim of pragmatic trials is to mimic real-life scenarios and gain maximum validity externally. They are usually commissioned by practitioners and policy makers to aid in their decision-making. They also provide a useful method of determining the causal relationship between the intervention and its effects. However, they shouldn't be used in lieu for explanation studies.
The idea of pragmatism is controversial and there are doubts about whether pragmatic trials should replace tests for explanations or if they are a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which prove the validity of a clinical or physiological hypothesis, and pragmatic trials, which guide the practice and policy decisions. They also proposed the framework for pragmatic trials, which they called PRECIS.2 This tool was designed to define the features of a practical trial that include the recruitment process, the design and delivery of the intervention, as well as the follow-up.
There is a growing increase in the number of pragmatic trials that have been published. A recent Medline search using the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. However, it is important to keep in mind that the majority of these trials were conducted in primary care settings.