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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are typically focused on the practical aspects of the research design, like the recruitment process and consent as well as adherence to the use of standard equipment.
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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and included participants from different geographical regions. This kind of heterogeneity, which is essential for pragmatic trials to be reliable and lessen the chance of bias is also essential. A high degree of heterogeneity, however, can cause problems with the trial design.
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Pragmatic trials are designed to replicate real-life situations and attain maximum external validity. Usually, they are ordered by policymakers and practitioners in order to inform their decisions. They can be used to determine the causality of an intervention and its effects. However, they should not be used in lieu for the use of explanation trials.
The pragmatism idea is controversial and there are concerns about whether pragmatic trials should be used to replace explanatory trials or 프라그마틱 슬롯 무료체험 complement them. Schwartz and Lellouch1 made an distinction between explanation-based studies, which confirm the physiological hypothesis or clinical hypothesis, and pragmatic trials that aid in the practice and policy decision-making. They also suggested an approach to pragmatic trials, dubbed PRECIS.2 This tool attempted to define the elements of a pragmatic study that include the recruitment process, the design and implementation of the intervention, and the follow-up.
There is a growing increase in the number pragmatic trials published. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials randomized to control (RCTs), yielded 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to keep in mind, however, that the majority of studies were conducted in primary care settings.