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Studies designed to provide insight into clinical practice in the real world are called pragmatic trials. They are typically described as focusing on practical aspects of design that include the recruitment process and consent, adhering and the use routinely available equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized a variety of investigators and included participants from various geographical areas. This type of heterogeneity is necessary for pragmatic trials to be valid and reduces bias in the results. However excessive heterogeneity could cause issues with the design of the trial.
Pragmatic Play is also a major player in the live casino market, offering an extensive selection of classic table games such as Blackjack and Roulette in various variations. The company's live studios in Romania and Malta offer an authentic gambling experience for customers, as well as an extensive selection of virtual betting options. The company also offers a variety of game shows that make online gambling fun and interactive. Some of these shows have live hosts, while others are hosted by prominent personalities from the industry.
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Pragmatic Play is renowned for its top-notch games, and also for providing an outstanding user experience. Its software is designed to work with mobile devices and is compatible with various languages. Despite its infancy, it has already established itself as a leading gaming platform for casinos. Its latest releases include Wolves, a 5-reel video slot that has a healthy RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.
Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are usually commissioned by practitioners and policy makers to aid in their decision-making. They are also a good way to identify the cause-effect relationship between the intervention and its effects. They should not, however be used to replace explanatory studies.
The pragmatism idea is controversial and there are concerns about whether pragmatic trials should replace explanatory tests or if they should serve as a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which support the validity of a physiological or clinical hypothesis, and pragmatic trials that aid in policy and practice decision-making. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool attempted to define the elements of a pragmatic research study that includes the recruitment, design, and delivery of the intervention, and follow-up.
There is a growing increase in the number of pragmatic trials published. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. It is important to note that the majority of these studies were conducted in primary-care settings.