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Pragmatic trials are those that are designed to provide information for the real-world practice of clinical. They are usually focused on the practical aspects of research design, like the recruitment and consent process, adherence, and the use of standard equipment.
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A pragmatic trial that uses different investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is essential for a pragmatic trial to be reliable and to reduce bias in the results, is also necessary. However, too much heterogeneity can result in problems with the design of the trial.
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Legality
Pragmatic Play has earned a name for itself by providing top-quality games and an outstanding user experience. Its software can be used on mobile devices and in multiple languages. Despite its infancy it has established itself as a leading casino gaming platform. Wolves is one of the most recent releases which is a five-reel slot machine that has a high RTP and impressive graphics. Other notable games include Wolf Gold and Chilli Heat.
The goal of pragmatic trials is to simulate real-life situations and achieve the highest level of validity externally. They are usually requested by policy makers and practitioners to inform their decision making. They are also a good method to determine the causality between an intervention and its results. They should not, however be used to replace explanation studies.
The pragmatism concept is controversial, and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested an distinction between explanation-based studies, which confirm the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the decision-making process for policy and practice. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a pragmatic research study which includes recruitment, design, implementation of the intervention and its follow-up.
There is a growing trend in the number of pragmatic trials published. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This is an indication that the health sciences community is becoming more acquaint to the issue of pragmatic thinking. It is important to keep in mind that the majority of these trials were conducted in primary care settings.