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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often focused on the practical aspects of research design, like recruitment and consent, adherence, and the use of routinely available equipment.
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Pragmatic, a software company, offers a variety of casino games for online gambling platforms. Its iGaming software is used by leading operators as well as casinos that are located in the land. The company offers front-end design tools, analysis tools, marketing, promotions payment systems, security, customer support and bug reporting. Additionally, the company provides its users a safe environment with high-quality graphics as well as gameplay.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed various investigators and included participants from different geographic areas. This type of heterogeneity that is crucial for a pragmatic trial to be reliable and lessen the chance of bias is also essential. Too much heterogeneity, however could cause issues with the trial design.
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Pragmatic Play has earned a reputation for providing high-quality games and a superior user experience. Its software can be used on mobile devices and in multiple languages. Despite its relative youth it has established itself as a top casino gaming platform. The most recent releases include Wolves 5 reel video slot with a healthy RTP and stunning graphics. Other notable games include Wolf Gold and Chilli Heat.
Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are usually commissioned by policymakers and practitioners in order to guide their decisions. They are also a good method to determine the cause-effect relationship between an intervention and its outcomes. However, they should not, be used to replace the need for explanation studies.
The pragmatism idea is controversial and there are doubts about whether pragmatic trials should be used to replace explanation tests or if they should serve as a complement to them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which support the physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform the practice and policy decision-making. They also proposed an approach to pragmatic trials, called PRECIS.2 This tool sought to define the features of a pragmatic trial which includes recruitment, design and delivery of the intervention, as well as monitoring.
There is a positive trend in the number of pragmatic trials that have been published. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. However, it is important to remember that the majority of these trials were conducted in primary care settings.