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Studies designed to provide insight into clinical practice in the real world are called pragmatic trials. They are often described as focusing on practical aspects of study design which include the recruitment and consent process, as well as adherence and the use of routinely available equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and participants from different geographical regions. This kind of heterogeneity, 무료슬롯 프라그마틱 슬롯 무료 (http://ezproxy.cityu.edu.hk) that is crucial for pragmatic trials to be valid and lessen the chance of bias is also essential. A high degree of heterogeneity, however, can cause problems with the trial design.
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The aim of pragmatic trials is to simulate real-life scenarios and to achieve maximum validity externally. They are usually requested by practitioners and policy makers to aid in their decision-making. They can also be a great method of determining the cause-effect relationship between an intervention and its outcomes. They should, however, not be used to replace the need for explanation studies.
The pragmatism idea is controversial, and there are questions about whether pragmatic trials should replace explanatory tests or if they should serve as a complement to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis as well as pragmatic trials, 프라그마틱 무료슬롯 which guide policy and practice decisions. They also suggested the framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the characteristics of a pragmatic trial, including the recruitment process, the design and implementation of the intervention, and the follow-up.
The number of pragmatic trials is growing. A recent Medline search using the terms pragmatic and naturalistic, restricted to randomized controlled trials (RCTs) produced 34 articles, as shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to keep in mind that the majority of these trials were conducted in primary care settings.