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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are typically described by their focus on practical aspects of study design that include recruitment and 프라그마틱 홈페이지 consent, adherence and the use of routinely available equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used various investigators and included participants from different geographical regions. This type of heterogeneity, which is vital for a pragmatic trial to be reliable and to reduce bias in the results is also essential. A high degree of heterogeneity, however can result in problems with the trial design.
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Pragmatic trials aim to mimic real-world situations and have the highest external validity. They are typically commissioned by policymakers and practitioners in order to inform their decisions. They are also a good way to identify the causal relationship between the intervention and its effects. However, they should not be used in lieu for 프라그마틱 정품인증 the use of explanation trials.
The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which confirm a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform the decision-making process for policy and practice. They also proposed the framework for pragmatic trials, dubbed PRECIS.2 This tool was designed to define the characteristics of a pragmatic study that include the recruitment process, the design and delivery of the intervention, as well as monitoring.
There is an encouraging increase in the number of pragmatic trials that have been published. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to note that the majority of these trials were conducted in primary care settings.