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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are usually focused on the practical aspects of study design, 프라그마틱 플레이 including the recruitment process and consent as well as adherence to the use of commonly available equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used different investigators and included participants from various geographical areas. This type of heterogeneity is necessary for practical trials to be valid and also helps reduce bias in the results. However, too much heterogeneity can result in problems with the trial design.
Pragmatic Play is also a major player in the live casino market, offering a wide selection of table games that are classic such as Blackjack and Roulette in various versions. The live studios of Pragmatic Play's offices in Romania and Malta offer customers an authentic experience in gambling and a wide variety of betting options via virtual. The company also has several games that make online gambling fun and interactive. Some of these shows feature live hosts, while others are hosted by famous personalities from the industry.
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Pragmatic trials seek to replicate real-life settings and achieve maximum external validity. They are usually commissioned by policymakers and practitioners to inform their decisions. They can also be used to assess the causality of an intervention and its results. They should, however, not be used to replace explanation studies.
The concept of pragmatism is controversial and there are concerns about whether pragmatic trials can replace explanatory tests or if they should serve as an alternative to them. Schwartz and Lellouch1 made an distinction between explanation-based studies, which prove a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, which inform the practice and policy decision-making. They also proposed the framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the characteristics of a pragmatic study, including the recruitment process, the design and implementation of the intervention, as well as monitoring.
The number of pragmatic trials is growing. A recent Medline search using the keywords naturalistic and pragmatic, limited to controlled trials randomized to control (RCTs), yielded 34 articles, which are shown in red in Figure 2. This is an indication that the health sciences community is becoming increasingly sensitized to the issue of pragmatism. It is important to remember, however, that the majority of these studies were conducted in primary-care settings.