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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are often described as focusing on practical aspects of designing a study which include the recruitment and consent process, as well as adherence and the use of routinely available equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used different investigators and included participants from different geographic areas. This type of heterogeneity that is crucial for a pragmatic trial to be valid and to reduce bias in the results is also essential. However excessive heterogeneity could cause issues with the design of the trial.
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Pragmatic trials are designed to replicate real-life situations and attain maximum external validity. They are usually requested by practitioners and policy makers to aid in their decision-making. They can also be a great way to identify the causality between the intervention and its effects. However, 프라그마틱 플레이 무료 (https://qna.Lrmer.com) they should not be used to replace explanatory studies.
The pragmatism idea is controversial and there are concerns regarding whether pragmatic trials could be used to replace explanation tests or if they should be an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which prove a physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform the practice and policy decision-making. They also suggested an approach to pragmatic trials, which they called PRECIS.2 This tool sought to define the features of a pragmatic study which includes recruitment, design and delivery of the intervention, as well as follow-up.
There is an encouraging increase in the number of pragmatic trials published. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. It is important to note, however, that the majority of studies were conducted in primary-care settings.