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Pragmatic trials are studies designed to inform real-world clinical practice. They are often characterized as a focus on the practical aspects of designing a study, including recruitment and consent, adherence and the use of routinely available equipment.
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A pragmatic study that involves various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for pragmatic trials to be able to prove their validity and helps to reduce bias in the results. However excessive heterogeneity could cause problems with the design of the trial.
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The goal of pragmatic trials is to mimic real-life scenarios and to achieve the highest level of validity externally. Usually, they are commissioned by policymakers and practitioners to help guide their decisions. They can also be used to assess the causality of an intervention with its outcomes. They should not, however, be used to replace the need for explanation studies.
The pragmatism idea is controversial and there are doubts about whether pragmatic trials can replace explanatory tests or if they should serve as an alternative to them. Schwartz and 프라그마틱 슬롯버프 홈페이지 (https://images.google.ad/) Lellouch1 suggested an distinction between explanation-based studies, which confirm the validity of a physiological or clinical hypothesis, and pragmatic trials that aid in policy and practice decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic study which includes the recruitment, design, and delivery of the intervention and follow-up.
The number of pragmatic trials is growing. A recent Medline search using the terms naturalistic and pragmatic, limited to randomized controlled trials (RCTs), yielded 34 articles, as shown in red in Figure 2. This indicates that the health science community is becoming more acquaint to the subject of pragmatics. It is important to keep in mind that the majority of these trials were conducted in primary care settings.