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Studies designed to provide insight into clinical practice in the real world are referred to as pragmatic trials. They are typically focused on the practical aspects of study design, such as recruitment and consent in adherence, as well as the use of commonly available equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and had participants from different geographical regions. This type of heterogeneity that is crucial for a pragmatic trial to be valid and lessen the chance of bias, 프라그마틱 공식홈페이지 (https://infozillon.Com) is also necessary. However excessive heterogeneity could lead to problems with the design of the trial.
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The goal of pragmatic trials is to mimic real-life situations and achieve maximum credibility externally. They are usually commissioned by practitioners and policy makers to aid in their decision-making. They are also a good method of determining the causal relationship between an intervention and its outcomes. However, they should not, be used to replace explanation studies.
The pragmatism idea is controversial and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm a physiological or clinical hypothesis as well as pragmatic trials, which inform the practice and policy decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a practical study that includes recruitment, design, implementation of the intervention and its follow-up.
The number of pragmatic trials is growing. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to note that the majority of these studies were conducted in primary care settings.