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Pragmatic trials are studies designed to inform real-world clinical practice. They are typically described by their focus on practical aspects of design that include recruitment and consent, adherence and the use of standard equipment.
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A pragmatic study that involves different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is necessary for pragmatic trials to be valid and also reduces the chance of bias in the results. However, too much heterogeneity can result in problems with the design of the trial.
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The goal of pragmatic trials is to replicate real-life situations and achieve the highest level of validity externally. They are usually requested by practitioners and policy makers to aid in their decision-making. They can also be used to assess the causality of an intervention and its results. However, 프라그마틱 카지노 프라그마틱 무료 슬롯 체험 - site, they should not be used to substitute for the use of explanation trials.
The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should replace tests for explanations or if they are an addition to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate the clinical or physiological hypothesis, and pragmatic trials that inform the practice and policy decisions. They also suggested a framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the elements of a practical trial which includes recruitment, design and delivery of the intervention, as well as monitoring.
The number of pragmatic trials is growing. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This is an indication that the health sciences community is becoming more sensitive to the issue of pragmatic thinking. However, it is important to note that the majority of these trials were conducted in primary care settings.