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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often described as a focus on the practical aspects of designing a study, including the recruitment process and consent, adhering and the use routinely available equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed various investigators and had participants from various geographical areas. This type of heterogeneity which is vital for pragmatic trials to be reliable and to reduce bias in the results is also essential. However, too much heterogeneity can cause problems with the design of the trial.
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The purpose of pragmatic trials is to mimic real-life scenarios and gain maximum credibility externally. They are typically commissioned by policymakers and practitioners in order to guide their decisions. They can also be used to determine the causality of an intervention and its effects. They should, however, not be used to replace explanatory studies.
The pragmatism concept is controversial, and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which support the physiological hypothesis or clinical hypothesis, and pragmatic trials that aid in the practice and policy decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic research study that includes the recruitment, design, and delivery of the intervention and follow-up.
There is an encouraging trend in the number of pragmatic trials published. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs), yielded 34 articles, as shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. However, 라이브 카지노 it is important to note that the majority of these trials were conducted in primary care settings.