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Pragmatic trials are studies designed to inform real-world clinical practice. They are often focused on the practical aspects of the study design, such as the recruitment and consent process, adherence, and the use of routinely available equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and participants from different geographic areas. This type of heterogeneity which is essential for pragmatic trials to be valid and to reduce bias in the results, is also necessary. However, too much heterogeneity, 프라그마틱 무료 프라그마틱 불법 (discover this info here) can cause problems with the trial design.
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The purpose of pragmatic trials is to mimic real-life scenarios and gain the highest level of validity externally. They are typically ordered by policymakers and practitioners to help guide their decisions. They can also be used to determine the causality of an intervention and its effects. However, they shouldn't be used as a substitute for the use of explanation trials.
The pragmatism concept is controversial, and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the clinical or physiological hypothesis, and pragmatic trials, which inform the policy and practice of. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the traits of a pragmatic research study which includes the recruitment, design, and delivery of the intervention and its follow-up.
The number of pragmatic trials is growing. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs) produced 34 articles, shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to note, however, that the majority of these studies were conducted in primary care settings.