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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are usually characterized by a focus on practical aspects of the research design, like the recruitment and consent process, adherence, and the use of commonly available equipment.
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A pragmatic trial that uses different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is essential for practical trials to be valid and reduces the chance of bias in the results. However, too much heterogeneity can lead to problems with the design of the trial.
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Pragmatic trials are designed to replicate real-world situations and have the highest external validity. They are typically commissioned by practitioners and policy makers to aid in their decision-making. They can be used to determine the causality of an intervention and its results. However, they shouldn't be used to substitute for explanatory trials.
The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate a physiological or clinical hypothesis and pragmatic trials, which guide the practice and policy decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool attempted to define the traits of a practical study that includes recruitment, design, delivery of the intervention and follow-up.
The number of pragmatic trials is growing. A recent Medline search using the keywords pragmatic and naturalistic, 프라그마틱 데모 프라그마틱 슬롯 무료 (visit the following web page) restricted to randomized controlled trials (RCTs), yielded 34 articles, shown in red in Figure 2. This is a sign that the health sciences community is becoming more sensitive to the subject of pragmatism. It is important to note that the majority of these studies were conducted in primary care settings.