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Studies designed to provide insight into clinical practice in the real world are referred to as pragmatic trials. They are typically described by their focus on practical aspects of designing a study, including the recruitment process and consent, adhering and the use of standard equipment.
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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which used various investigators and had participants from different geographical regions. This type of heterogeneity, which is essential for a pragmatic trial to be reliable and reduce bias in results, is also necessary. However excessive heterogeneity could cause problems with the design of the trial.
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Legality
Pragmatic Play has earned a reputation for providing top-notch games and an exceptional user experience. Its software is designed to work with mobile devices and is compatible with multiple languages. Despite its relative youth it has established itself as a leading gaming platform for casinos. Wolves is one of its latest releases, a 5-reel slot machine that has a high RTP and stunning graphics. The other notable titles include Wolf Gold and Chilli Heat.
The purpose of pragmatic trials is to mimic real-life scenarios and gain maximum credibility externally. They are usually requested by policy makers and practitioners to aid in their decision-making. They can be used to determine the causal relationship between an intervention with its outcomes. However, they shouldn't be used as a substitute for the use of explanation trials.
The idea of pragmatism is controversial, and there are questions regarding whether pragmatic trials could replace tests for explanations or if they should serve as a complement to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate a physiological or clinical hypothesis, and pragmatic trials that inform policy and practice decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the elements of a pragmatic study that includes recruitment, design, delivery of the intervention, and follow-up.
The number of pragmatic trials is growing. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials that are randomized (RCTs), yielded 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community is becoming more acquaint to the subject of pragmatics. It is important to keep in mind that the majority of these studies were conducted in primary care settings.