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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are often characterized by a focus on practical aspects of the study design, including the recruitment and consent process in adherence, as well as the use of standard equipment.
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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized a variety of investigators and had participants from various geographical areas. This kind of heterogeneity is necessary for practical trials to be valid, and it also reduces the chance of bias in the results. However, too much heterogeneity can lead to problems with the design of the trial.
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The goal of pragmatic trials is to mimic real-life scenarios and gain the highest level of validity externally. They are typically commissioned by practitioners and policy makers to inform their decision making. They can also be a great method of determining the causality between an intervention and its outcomes. They should, however, not be used to replace explanatory studies.
The idea of pragmatism is controversial and there are concerns about whether pragmatic trials should replace explanatory tests or if they are a complement to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove a physiological or clinical hypothesis, and pragmatic trials that inform policy and practice decisions. They also suggested an approach to pragmatic trials, dubbed PRECIS.2 This tool attempted to define the elements of a pragmatic study, including the recruitment process, the design and implementation of the intervention, as well as the follow-up.
The number of pragmatic trials is increasing. A recent Medline search using the keywords pragmatic and naturalistic, 라이브 카지노 restricted to randomized controlled trials (RCTs) produced 34 articles, shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to keep in mind that the majority were conducted in primary-care settings.