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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often characterized as a focus on the practical aspects of study design which include the recruitment process and consent, adhering and the use of routinely available equipment.
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A practical trial that employs different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is essential for pragmatic trials to be able to prove their validity and also helps reduce the chance of bias in the results. However, too much heterogeneity can result in issues with the design of the trial.
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Pragmatic trials seek to replicate real-life settings and achieve maximum external validity. Usually, they are ordered by policymakers and practitioners to inform their decisions. They can also be a great method to determine the causal relationship between the intervention and its effects. However, they shouldn't be used as a substitute for the use of explanation studies.
The pragmatism idea is controversial and there are concerns regarding whether pragmatic trials could replace explanatory tests or if they should be an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate the validity of a clinical or physiological hypothesis, and pragmatic trials, which guide the policy and 프라그마틱 슬롯 practice of. They also proposed an approach to pragmatic trials, called PRECIS.2 This tool sought to define the elements of a pragmatic trial that include recruitment, design and delivery of the intervention, as well as follow-up.
The number of pragmatic trials is growing. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. However, it is important to note that the majority of these trials were conducted in primary care settings.