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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are typically described as a focus on the practical aspects of study design, including the recruitment process and consent, adhering and the use of standard equipment.
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A pragmatic study that involves a variety investigators and includes participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is required for practical trials to be valid and helps reduce bias in the results. However too much heterogeneity could lead to problems with the design of the trial.
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Pragmatic trials are designed to replicate real-life situations and attain maximum external validity. Usually, they are commissioned by policymakers and 프라그마틱 무료 슬롯버프 - Https://Justbookmark.Win - practitioners in order to guide their decisions. They can also be used to assess the causality of an intervention with its outcomes. However, they shouldn't be used as a substitute for the use of explanation studies.
The concept of pragmatism is controversial and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove a physiological or clinical hypothesis, and pragmatic trials, which guide the practice and policy decisions. They also suggested the framework for pragmatic trials, dubbed PRECIS.2 This tool was designed to define the elements of a pragmatic study, including recruitment, design and delivery of the intervention, as well as monitoring.
There is a growing increase in the number of pragmatic trials that are published. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to note that the majority were conducted in primary-care settings.