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Pragmatic trials are studies designed to inform real-world clinical practice. They are typically characterized by a focus on the practical aspects of study design, including recruitment and consent, adherence, and the use of commonly available equipment.
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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and had participants from different geographic areas. This type of heterogeneity is essential for pragmatic trials to be able to prove their validity, and it also helps to reduce the chance of bias in the results. However, too much heterogeneity can lead to issues with the design of the trial.
Pragmatic Play Pragmatic Play, a major player on the live casino market, offers a variety of classic table games like Blackjack and Roulette. The company's live studios in Romania and Malta offer a real-life gaming experience for its customers, as well as an extensive selection of virtual betting options. The company also has created various interactive games to make gambling online enjoyable. Some of these shows feature live hosts, whereas others are hosted by celebrities from the industry.
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Legality
Pragmatic Play is known for its top-notch games, and for offering an exceptional user experience. The software is available on mobile devices and in multiple languages. It has been recognized as one of the top casino gaming platforms despite its relative infancy. Wolves is one of its latest releases which is a five-reel slot machine with a hefty RTP and impressive graphics. The other notable titles include Wolf Gold and Chilli Heat.
Pragmatic trials are designed to replicate real-life situations and attain maximum external validity. They are usually commissioned by policy makers and practitioners to aid in their decision-making. They can be used to determine the causality of an intervention and its results. However, they should not be used to replace explanation studies.
The concept of pragmatism is controversial and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which prove a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform policy and practice decision-making. They also suggested the framework for pragmatic trials, which they called PRECIS.2 This tool attempted to define the elements of a pragmatic study that include recruitment, design and delivery of the intervention, as well as monitoring.
The number of pragmatic trials is growing. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This is an indication that the health sciences community is becoming increasingly sensitized to the subject of pragmatics. It is important to note that the majority of these trials were conducted in primary care settings.