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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are typically described by their focus on practical aspects of designing a study that include the recruitment process and consent, adhering and the use of standard equipment.
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A pragmatic trial that uses different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is essential for pragmatic trials to be valid and lessen the chance of bias is also essential. A high degree of heterogeneity, however, 무료 프라그마틱 슬롯 조작 (just click the following website) can cause problems with the design of the trial.
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The purpose of pragmatic trials is to mimic real-life scenarios and gain maximum validity externally. They are usually commissioned by practitioners and policy makers to inform their decision making. They also provide a useful way to identify the causal relationship between the intervention and its effects. They should, however, not, be used to replace the need for explanation studies.
The pragmatism concept is controversial and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 made the distinction between explanation studies, which support a physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the decision-making process for policy and practice. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool attempted to define the traits of a practical study that includes the recruitment, design, and delivery of the intervention, and follow-up.
There is an encouraging increase in the number of pragmatic trials published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs) resulted in 34 articles, shown in red in Figure 2. This indicates that the health sciences community is becoming increasingly sensitized to the issue of pragmatic thinking. It is important to note, however, that the majority of studies were conducted in primary-care settings.