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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are usually characterized by a focus on the practical aspects of the study design, such as recruitment and consent as well as adherence to the use of commonly available equipment.
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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and included participants from different geographic areas. This type of heterogeneity is essential for practical trials to be valid and also reduces the chance of bias in the results. However, too much heterogeneity can result in problems with the trial design.
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The purpose of pragmatic trials is to mimic real-life situations and achieve the highest level of validity externally. They are usually commissioned by practitioners and 프라그마틱 슬롯 무료 policy makers to guide their decision-making. They can also be used to determine the causal relationship between an intervention and its results. However, they shouldn't be used as a substitute for explanatory trials.
The idea of pragmatism is controversial and there are concerns about whether pragmatic trials can replace explanatory tests or if they should serve as a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate the clinical or physiological hypothesis as well as pragmatic trials that inform the policy and practice of. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic study, including recruitment, design, implementation of the intervention, and follow-up.
There is an encouraging increase in the number of pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs), yielded 34 articles, as shown in red in Figure 2. This is an indication that the health sciences community is becoming more sensitive to the subject of pragmatic thinking. It is important to note that the majority of these studies were conducted in primary care settings.