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Studies designed to provide insight into clinical practice in the real world are called pragmatic trials. They are typically described as focusing on practical aspects of designing a study which include recruitment and consent, adherence and the use of routinely available equipment.
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A practical trial that employs a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity that is crucial for a pragmatic trial to be valid and reduce bias in results, is also necessary. However, too much heterogeneity can result in problems with the design of the trial.
Pragmatic Play Pragmatic Play, a major player on the live casino market offers a variety of classic table games such as Blackjack and Roulette. The company's live studios in Romania and Malta offer a real-life gaming experience for its customers, as well as a full suite of virtual betting options. The company also offers a variety of games which make online gambling fun and interactive. Some of these shows feature a live host, while others are hosted by famous personalities from the industry.
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The aim of pragmatic trials is to mimic real-life scenarios and to achieve the highest level of validity externally. Usually, they are ordered by policymakers and practitioners to help inform their decisions. They are also a good method of determining the causal relationship between the intervention and its effects. However, they should not be used to replace explanatory studies.
The pragmatism idea is controversial, and there are questions about whether pragmatic trials can be used to replace explanation tests or if they should serve as an alternative to them. Schwartz and Lellouch1 suggested an distinction between explanation-based studies, which prove the validity of a physiological or clinical hypothesis, and pragmatic trials, which inform the practice and policy decision-making. They also suggested the framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the features of a pragmatic study, including the recruitment process, the design and implementation of the intervention, as well as the follow-up.
There is a positive increase in the number pragmatic trials published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs), yielded 34 articles, shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to note that the majority of these trials were conducted in primary care settings.