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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are usually characterized by a focus on practical aspects of the study design, such as the recruitment and consent process in adherence, as well as the use of commonly available equipment.
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A pragmatic trial that uses different investigators and 프라그마틱 슬롯무료 participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is necessary for practical trials to be valid and reduces the chance of bias in the results. However, too much heterogeneity could cause issues with the trial design.
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Pragmatic trials are designed to replicate real-world situations and have the highest external validity. They are usually requested by practitioners and policy makers to inform their decision making. They also provide a useful way to identify the cause-effect relationship between the intervention and its effects. However, they should not be used as a substitute for the use of explanation studies.
The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis and pragmatic trials that inform policy and practice decisions. They also suggested the framework for pragmatic trials, called PRECIS.2 This tool attempted to define the characteristics of a practical trial that include recruitment, 무료슬롯 프라그마틱 (Www.Buy1On1.Com) design and delivery of the intervention, and follow-up.
The number of pragmatic trials is increasing. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs) resulted in 34 articles, shown in red in Figure 2. This indicates that the health sciences community is becoming more acquaint to the subject of pragmatic thinking. It is important to keep in mind that the majority of these studies were conducted in primary care settings.