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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often characterized by their focus on practical aspects of study design, including the recruitment and consent process, as well as adherence and the use of routinely available equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and had participants from different geographical regions. This kind of heterogeneity is necessary for pragmatic trials to be valid, and it also helps to reduce the chance of bias in the results. However too much heterogeneity could result in issues with the design of the trial.
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Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are usually requested by policy makers and practitioners to guide their decision-making. They can also be used to assess the causal relationship between an intervention and its results. However, they should not be used as a substitute for the use of explanation trials.
The concept of pragmatism is controversial and there are concerns about whether pragmatic trials can replace explanatory tests or if they are an addition to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which prove the clinical or 프라그마틱 무료 슬롯버프 physiological hypothesis as well as pragmatic trials, which inform the policy and practice of. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the elements of a practical study that includes the recruitment, design, and delivery of the intervention and follow-up.
There is a growing trend in the number of pragmatic trials that are published. A recent Medline search using the keywords naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs) produced 34 articles, as shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. However, it is important to keep in mind that the majority of these trials were conducted in primary care settings.