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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often characterized as focusing on practical aspects of designing a study, including the recruitment process and consent, adhering and the use of standard equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed various investigators and participants from different geographical regions. This type of heterogeneity which is essential for pragmatic trials to be reliable and to reduce bias in the results, is also necessary. However, too much heterogeneity can result in problems with the design of the trial.

Pragmatic Play Pragmatic Play, a major player on the live casino market, offers an array of traditional table games like Blackjack and Roulette. The live studios of Pragmatic Play in Romania and Malta provide customers with an authentic experience in gambling as well as a broad selection of virtual betting options. The company also hosts a variety of game shows which make online gambling enjoyable and engaging. Some of these shows have live hosts, whereas others are hosted by prominent personalities from the industry.

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Pragmatic Play is known for its top-notch games, and also for providing an outstanding user experience. Its software is accessible on mobile devices and in a variety of languages. It has established itself as one of the top casino gaming platforms despite its relatively young age. The most recent releases include Wolves which is a five-reel video slot with a healthy RTP and stunning graphics. Other notable games include Wolf Gold and Chilli Heat.

Pragmatic trials are designed to replicate real-world situations and have the highest external validity. Usually, they are requested by practitioners and policymakers to help inform their decisions. They can be used to determine the causal relationship between an intervention and its effects. They should, however, not, be used to replace explanation studies.

The concept of pragmatism is controversial, and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which prove a physiological or clinical hypothesis as well as pragmatic trials, which guide the policy and practice of. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the elements of a pragmatic research study, including recruitment, design, implementation of the intervention, and follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the keywords pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs), yielded 34 articles, which are shown in red in Figure 2. This indicates that the health science community is becoming more sensitive to the subject of pragmatics. It is important to keep in mind, however, that the majority were conducted in primary-care settings.