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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often described by their focus on practical aspects of design that include the recruitment process and consent, adhering and the use of standard equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized a variety of investigators and participants from various geographical areas. This kind of heterogeneity, which is essential for a pragmatic trial to be reliable and lessen the chance of bias, is also necessary. However, too much heterogeneity can result in problems with the trial design.

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Pragmatic trials seek to replicate real-world situations and have the highest external validity. They are typically commissioned by policy makers and practitioners to inform their decision making. They can be used to determine the causal relationship between an intervention and its effects. However, 프라그마틱 슈가러쉬 they should not be used as a substitute for explanation studies.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should replace explanatory tests or if they are an alternative to them. Schwartz and Lellouch1 made a distinction between explanatory studies, which prove the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the practice and policy decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a pragmatic study which includes recruitment, design, delivery of the intervention, and follow-up.

There is a growing trend in the number of pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs), yielded 34 articles, shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to note, however, that the majority were conducted in primary-care settings.