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Pragmatic trials are those that are designed to inform the practice of clinical trials in real life. They are often described as focusing on practical aspects of design that include recruitment and consent, adherence and the use routinely available equipment.

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A practical trial that employs various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, that is crucial for a pragmatic trial to be valid and 프라그마틱 슬롯 무료체험 to reduce bias in the results, is also necessary. However excessive heterogeneity could cause problems with the design of the trial.

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Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. They are usually ordered by policymakers and practitioners to help guide their decisions. They can also be a great method of determining the causal relationship between an intervention and its results. They should, however, not, be used to replace the need for explanation studies.

The pragmatism idea is controversial and there are doubts about whether pragmatic trials should be used to replace explanation tests or if they should serve as a complement to them. Schwartz and Lellouch1 made a distinction between explanatory studies, which prove a physiological hypothesis or clinical hypothesis, and pragmatic trials that aid in the decision-making process for policy and practice. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the elements of a pragmatic study, including the recruitment, design, and delivery of the intervention, and follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials that are randomized (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to note that the majority of studies were conducted in primary-care settings.