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Pragmatic trials are trials designed to provide information for the practice of clinical trials in real life. They are often characterized by a focus on the practical aspects of the study design, including recruitment and consent as well as adherence to the use of standard equipment.
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A practical trial that employs various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is vital for pragmatic trials to be reliable and lessen the chance of bias, is also necessary. However, too much heterogeneity, can cause problems with the trial design.
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Pragmatic trials seek to replicate real-life settings and achieve maximum external validity. They are usually ordered by policymakers and practitioners to help inform their decisions. They can be used to determine the causality of an intervention with its outcomes. They should, however, not, be used to replace explanatory studies.
The pragmatism idea is controversial and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm the clinical or physiological hypothesis as well as pragmatic trials, which inform the policy and practice of. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic research study that includes recruitment, design, delivery of the intervention and 프라그마틱 공식홈페이지 홈페이지 (Thekiwisocial.Com) follow-up.
The number of pragmatic trials is increasing. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming more acquaint to the issue of pragmatic thinking. It is important to keep in mind that the majority of these trials were conducted in primary care settings.