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Pragmatic trials are studies designed to provide information for the practice of clinical trials in real life. They are often described as a focus on the practical aspects of study design, including recruitment and consent, adherence and the use of standard equipment.

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RTP

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A pragmatic study that involves various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is essential for pragmatic trials to be valid and reduce bias in results, is also necessary. However excessive heterogeneity could lead to issues with the design of the trial.

Pragmatic Play is one of the biggest players on the live casino market, offers a variety of classic table games like Blackjack and Roulette. The live studios of the company in Romania and Malta provide a genuine gaming experience for its customers, as well as a full suite of virtual betting options. The company also offers a variety of game shows which make online gambling enjoyable and engaging. Some of these shows are hosted live and some include famous people from the industry.

Mobile compatibility

Pragmatic Play is a new player in the world of online casinos, but it has made a name for itself through its mobile-friendly slot machines. Their games are optimized for mobile devices and run on HTML5 technology. They are also licensed and regulated by reputable gaming authorities, which ensure fairness and transparency. This is a good indicator for players, since it implies that the games are checked and verified to ensure that the results of each round are fair and impartial.

Pragmatic Play offers not only mobile-friendly slot machines as well as table games and live casino. The company is licensed and regulated by several regulatory bodies which include the Malta Gaming Authority and UK Gambling Commission. Its games are backed by the latest encryption technology and the security team is always available to assist players solve any issues they might face.

The majority of Pragmatic Play slot games feature traditional themes as well as modern graphics, making them popular with both newcomers and seasoned players. A lot of them offer progressive jackpots and come with multiple bonus rounds and paylines. They are also not very volatile, so you can expect to have a long-lasting gaming session with them.

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Legality

Pragmatic Play is known for its top-notch games, and for providing a superior user experience. Its software is designed to work with mobile devices and supports different languages. Despite its relatively young age, it has already established itself as a leading casino gaming platform. Its latest releases include Wolves 5 reel video slot with a healthful RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

The goal of pragmatic trials is to simulate real-life scenarios and gain maximum validity externally. They are typically commissioned by policymakers and practitioners in order to inform their decisions. They can be used to determine the causality of an intervention with its outcomes. However, they should not be used to replace explanatory studies.

The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the clinical or physiological hypothesis and pragmatic trials, which inform the practice and policy decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the elements of a practical study which includes recruitment, design, delivery of the intervention and its follow-up.

The number of pragmatic trials is growing. A recent Medline search using the keywords pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs) produced 34 articles, shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to remember, however, that the majority were conducted in primary-care settings.