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Pragmatic trials are those that are designed to inform real-world clinical practice. They are typically characterized by a focus on the practical aspects of the research design, like the recruitment process and consent in adherence, as well as the use of standard equipment.
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Pragmatic Software, a software firm, offers a variety of casino games to online gambling platforms. Pragmatic's iGaming solutions are utilized by the most reputable operators as well as casinos with a physical location. The company provides front-end tools for design, analysis, promotions, marketing and payment systems, as well as security, customer support and bug reporting. Additionally, the company provides its players a safe and secure environment with high-quality graphics and gameplay.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and participants from different geographic areas. This kind of heterogeneity is necessary for pragmatic trials to be valid, and it also helps reduce bias in the results. However, too much heterogeneity, can cause problems with the design of the trial.
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Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are usually commissioned by policymakers and practitioners to guide their decisions. They are also a good way to identify the causal relationship between an intervention and its outcomes. They should not, however be used to replace explanation studies.
The pragmatism idea is controversial and there are concerns about whether pragmatic trials should replace explanatory tests or if they should serve as an addition to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm a physiological or clinical hypothesis as well as pragmatic trials, which inform the policy and practice of. They also proposed an approach to pragmatic trials, called PRECIS.2 This tool attempted to define the elements of a practical trial which includes recruitment, design and delivery of the intervention, as well as follow-up.
The number of pragmatic trials is increasing. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. However, it is important to note that the majority of these trials were conducted in primary care settings.