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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are typically described as focusing on practical aspects of study design that include the recruitment and consent process, 프라그마틱 as well as adherence and the use of standard equipment.

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A pragmatic trial that uses different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, that is crucial for pragmatic trials to be reliable and lessen the chance of bias, is also necessary. However too much heterogeneity could result in issues with the design of the trial.

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Pragmatic trials aim to mimic real-life situations and attain maximum external validity. They are typically commissioned by policymakers and practitioners in order to inform their decisions. They can also be used to assess the causal relationship between an intervention and its results. However, they should not be used to substitute for explanatory studies.

The idea of pragmatism is controversial and there are concerns about whether pragmatic trials should replace explanatory tests or if they should be an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm a physiological or clinical hypothesis, and pragmatic trials, which guide the practice and policy decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a practical study that includes the recruitment, design, and delivery of the intervention and its follow-up.

There is a growing trend in the number of pragmatic trials that are published. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. It is important to note that the majority of studies were conducted in primary-care settings.