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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are usually characterized by a focus on the practical aspects of research design, like recruitment and consent in adherence, as well as the use of routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and included participants from different geographical regions. This kind of heterogeneity is essential for 프라그마틱 슬롯 하는법 무료체험 (images.Google.co.za) practical trials to be valid, and it also helps reduce bias in the results. A high degree of heterogeneity, however can result in problems with the design of the trial.

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The aim of pragmatic trials is to simulate real-life scenarios and to achieve maximum validity externally. They are typically commissioned by policymakers and practitioners to inform their decisions. They can also be used to determine the causal relationship between an intervention and its effects. However, they should not be used to substitute for explanation trials.

The pragmatism concept is controversial and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm the validity of a clinical or physiological hypothesis, and pragmatic trials that inform the practice and policy decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool attempted to define the elements of a practical study that includes the recruitment, design, and delivery of the intervention, and follow-up.

There is a positive increase in the number pragmatic trials that are published. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This is an indication that the health science community is becoming more sensitive to the issue of pragmatic thinking. However, it is important to remember that the majority of these trials were conducted in primary care settings.